The article is devoted to an experimental study of the pharmacokinetics of gentamicin in rats with lymphotropic pretracheal and intramuscular routes of administration. Data on the concentration of the antibiotic in the blood and tissues of the respiratory organs of rats in dynamics are given, it is shown that the method of lymphotropic pretracheal administration provides higher concentrations of the antibiotic in comparison with the intramuscular method. The high therapeutic efficiency of this method can be achieved due to the presence of connections between the lymphatic system, as well as organs and tissues. This circumstance allows you to deliver the drug to the affected organ directly. In addition, in the case of lymphotropic therapy in the focus, the optimal concentration of the drug is maintained for 24 hours. So there is no need for frequent administration of the drug (for example, with antibiotic therapy), you can reduce the course and daily doses of drugs. The drug, which is administered lymphotropically, is not able to have a toxic effect on the intestines, kidneys, liver, since only a tiny part of the drug enters the bloodstream.

To obtain an adequate qualitative assessment of the activities of the medical staff of the rural area, a survey of doctors and paramedical staff was conducted, data on the age structure, length of service in general and in the specialty, issues of assessing the performance of medical staff and quality control were analyzed. We used sociological research methods - a survey of paramedical personnel was conducted on the basis of the central district hospital of the district. The data of a survey of 60 female paramedical workers were analyzed. The practical significance of the study is to obtain and process data on the performance of the nursing staff of the central district hospital in order to develop recommendations aimed at eliminating a number of factors that negatively affect health and quality of work, which can serve as an obstacle to professional activity

The article presents the available literature data on combined pathologies with hereditary coagulopathy and includes our own statistical calculations and 4 clinical cases of a combination of Hemophilia A, von Willebrand disease with hard palate defects, the genetic locus of which is located in the immediate vicinity of the F8 gene. Mutations and changes in the protein structure of the F8 gene can lead to the development of both sporadic forms of hemophilia and occur in patients with a hereditary predisposition. Research methods: coagulological, examination and questionnaire data. Conclusion: it is necessary to widely introduce methods of molecular genetic research and prenatal diagnostics in Uzbekistan.

To date, the pathogenesis and morphogenesis of COVID-19 have not been studied in depth, and therefore, in this work, the goal is to study the damage to the parenchymal-stromal elements of the myocardium in COVID-19. The material for the study was pieces from the myocardium of the ventricular wall of 26 patients who died from COVID-19 at the age of 28 to 56 years. The results of a morphological study showed that edema and mucoid swelling of the interstitial tissue of the myocardium in COVID-19 occurs due to the accumulation of hyaluronan, the development of dystrophy, dysregeneration and inflammation of blood vessels and connective tissue structures. In the myocardial parenchyma, contracture disorders, homogeneous compaction of the cytoplasm of cardiomyocytes, disappearance of the transverse striation of myofibrils, focal development of basophilia, PAS-positive metaplasia of cardiomyocytes, fragmentation, degeneration and necrobiosis of muscle fibers were noted; compaction, deformation and destruction of the nuclei of cardiomyocytes. Injuries to cardiomyocytes are first manifested by sarcoplasm vacuolization, a change in the coloration and shape of the nucleus, then enlargement and hyperchromasia of the nucleus in the form of dysplasia occur, homogenization, metachromasia and blue staining are noted from the sarcoplasm, followed by lysis of the nucleus; in the future, metachromasia covers the entire cytoplasm of the cardiomyocyte and the cell dies.

The development of cytopenic syndrome in chronic liver diseases accompanied by portal hypertension is associated by many researchers with splenomegaly. The article is devoted to the study of the dependence of hypersplenism (cytopenic syndrome) on the magnitude of splenomegaly and the level of portal hypertension, as well as the severity of liver damage in intra- and extrahepatic blockade of portal circulation. The analysis was carried out in 25 children suffering from extrahepatic PH and 46 children with intrahepatic blockade of the portal circulation, who were hospitalized at the age of 3 to 14 years. The development of cytopenic syndrome in children with both intra- and extrahepatic forms of portal hypertension does not depend on the size of splenomegaly. It is reasonable to believe that the cytopenia that develops in children with portal hypertension and splenomegaly is more associated with liver damage and intrahepatic blockade of the portal circulation, as well as the level of portal hypertension.

The development of cytopenic syndrome in chronic liver diseases accompanied by portal hypertension is associated by many researchers with splenomegaly. The article is devoted to the study of the dependence of hypersplenism (cytopenic syndrome) on the magnitude of splenomegaly and the level of portal hypertension, as well as the severity of liver damage in intra- and extrahepatic blockade of portal circulation. The analysis was carried out in 25 children suffering from extrahepatic PH and 46 children with intrahepatic blockade of the portal circulation, who were hospitalized at the age of 3 to 14 years. The development of cytopenic syndrome in children with both intra- and extrahepatic forms of portal hypertension does not depend on the size of splenomegaly. It is reasonable to believe that the cytopenia that develops in children with portal hypertension and splenomegaly is more associated with liver damage and intrahepatic blockade of the portal circulation, as well as the level of portal hypertension.

It has been presented results of a research of thermotopography of skin of newborns, the right-left gradients of skin temperature on separate body parts at newborns depending on a sex. In the first month of life the children has high activity thermogenesis, at the expense of the brown fatty tissue having high power potential. Boys have an activation of heat production of brown fat high, than at girls that provides more high temperature on some body parts. Results of a research has been presented, that the newborns born with normal basic anthropometrical data are not uniform in a maturity and temperature gradients in comparison on a sex.

It has been presented results of a research of thermotopography of skin of newborns, the right-left gradients of skin temperature on separate body parts at newborns depending on a sex. In the first month of life the children has high activity thermogenesis, at the expense of the brown fatty tissue having high power potential. Boys have an activation of heat production of brown fat high, than at girls that provides more high temperature on some body parts. Results of a research has been presented, that the newborns born with normal basic anthropometrical data are not uniform in a maturity and temperature gradients in comparison on a sex.

The article presents the available literature data on combined pathologies with hereditary coagulopathy and includes our own statistical calculations and 4 clinical cases of a combination of Hemophilia A, von Willebrand disease with hard palate defects, the genetic locus of which is located in the immediate vicinity of the F8 gene. Mutations and changes in the protein structure of the F8 gene can lead to the development of both sporadic forms of hemophilia and occur in patients with a hereditary predisposition. Research methods: coagulological, examination and questionnaire data. Conclusion: it is necessary to widely introduce methods of molecular genetic research and prenatal diagnostics in Uzbekistan.

The article presents the available literature data on combined pathologies with hereditary coagulopathy and includes our own statistical calculations and 4 clinical cases of a combination of Hemophilia A, von Willebrand disease with hard palate defects, the genetic locus of which is located in the immediate vicinity of the F8 gene. Mutations and changes in the protein structure of the F8 gene can lead to the development of both sporadic forms of hemophilia and occur in patients with a hereditary predisposition. Research methods: coagulological, examination and questionnaire data. Conclusion: it is necessary to widely introduce methods of molecular genetic research and prenatal diagnostics in Uzbekistan.